Mike Selvon asked:


In 2000, just four years before his death, “Superman” actor Christopher Reeves wrote in TIME Magazine: “It is our responsibility to do everything possible to protect the quality of life of the present and future generations. A critical factor will be what we do with human embryonic stem cells.” He went on to note the potential for treating Alzheimer’s, heart disease, Lou Gehrig’s disease and spinal cord injuries like he had with a simple, basic embryonic stem cell; “the body’s repair kit.” While controversy proliferated during the George Bush presidency, millions suffered. Today, there is a more liberal policy regarding stem cell research funding.

“The likelihood of something going wrong is pretty high,” warns Arnold Kriegstein of UC San Francisco’s Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. “Something like tumors are probably going to happen. This is an area where the risks are great. The public has to be prepared.” He points to a recent story of a teenage boy who traveled from Israel to Russia to undergo stem cell therapies only to find he had little more than a brand new brain tumor four years later. Embryonic stem cell research is far from perfect, Kriegstein admits, and it could take many years before taxpayers see a return on their $3 billion investment.

Even though $3 billion has been allocated for stem cell research funding, the cost of embryonic stem cell research is high. A human clinical trial, for instance, could cost hundreds of millions of dollars. Nothing is more substantive than a successful human trial, of course, yet what if it doesn’t work? “We all want the same thing – we want to see regenerative medicine work,” said Bruce Conklin at the J. David Gladstone Institutes. “Although there’s $2 billion left to give out, that’s actually a very small amount of money. Now, if that’s all spent on clinical trials that don’t tell us anything because they don’t work, that’s a missed opportunity.”

Despite the limitations of the embryonic stem cell, there have been some significant discoveries in recent years. For instance, Japanese scientist Shinya Yamanaka found that adult stem cells could be transformed into pluripotent stem cells, which carry an infinite potential for transforming into other cells. It was also found that the human body tends to accept these new adult cells more than embryonic cells. The added significance is that an embryo needn’t be destroyed to advance science, which is what many pro-lifers had against stem cell research.

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Michael Callen asked:


Stem Cell Update

Stem cell differences. Stem cells are different from other cells of the body in that they have the ability to differentiate into other cell/tissue types. This ability allows stem cells to replace cells that have been damaged or died. With this ability, they have been used in therapies to replace cells/tissues in patients who have certain diseases or defects.

Focus changes from genes to stem cells. During the 1990′s, the research for many debilitating diseases was focused on gene therapy, which involves putting certain genes into cells in a patient. In the 21st century, the focus has shifted from gene therapy to stem cell therapy.

Stem cell therapy offers promises. Stem cell therapy offers the promises that gene therapy held, without the difficulty and expense. Because stem cells are the body’s master cells – having the ability to become other kinds of cells – theory and results hold that the difficult work of gene therapy can be done by the stem cell itself.

Stem Cell Debate. Is There A Solution? Stem Cell research and stem cell therapy are two subjects about which nearly everyone has an opinion. The crux of the issue is that there are two main sources of stem cells: stem cell donors or stem cell patients.

The donors can be from living humans or fetal tissue, and this is typically where the main argument comes in to play. Those who are opposed to abortion do not want the by-product of an abortion (in this case – embryotic stem cells) to become a cottage industry. This is understandable.

On the other hand, adult stem cells can be extracted from the bone marrow of the patient or a living donor, and then cultured, and finally injected into the patient. While this kind of therapy seems to be quite effective, it is a very expensive procedure that is out of reach for most people.

Fortunately, there is a third option that is simple, safe, and affordable for everyone; and best of all – it is not objectionable to parties on either side of the stem cell debate. This stem cell therapy alternative involves a natural botanical extract that has been shown to stimulate the release of adult stem cells within the patient.

Triple-blind clinical trials show that one gram of this botanical stem cell enhancer increases the number of adult stem cells in circulation by 25 – 30% for several hours.

Stem Cell Enhancers – A Breakthrough. Scientists have identified a breakthrough, natural botanical extract that supports wellness by helping your body maintain healthy stem cell physiology. Available without a prescription, this product is from the latest phytoceutical product category called “stem cell enhancers”.

What are Stem Cell Enhancers? Recent scientific developments have revealed that stem cells derived from the bone marrow, travel throughout the body, and act to support optimal organ and tissue function. Stem cell enhancers are products that support the natural role of adult stem cells.

How can Stem Cell Enhancers Benefit You? As you age, the number and quality of stem cells that circulate in your body gradually decrease, leaving your body more susceptible to injury and other age-related health challenges. Just as antioxidants are important to protect your cells from “free radical” damage, stem cell enhancers are equally important to support your stem cells in maintaining proper organ and tissue functioning in your body.

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Rosy Vohra asked:


Gene is the structural and functional unit of life. These basic entities are the vehicles that carry entire genetic information encoding for every function of the body. This it does so by encoding for specific amino acids. Several amino acids team up to build proteins. It is these proteins which will then be an integral part of hormones, enzymes and other essential components which will regulate the body mechanisms. In most cases one gene codes for one amino acid and several amino acids make for a single protein. Thus in the built up of a single protein which can serve as enzyme or hormone is made up by the instructions coming from a group of inter-related genes.

It is essential to understand that in the event of any alteration in the structure of gene, defective commands will be given causing the formation of wrong structure of protein. The alteration takes place by way of mutation caused due to natural aging process, environmental factors, radioactive components, ultra violet rays and others of the kind. This altered protein will not be similar to the protein desired and needed by the body to perform the required function. This means the metabolism is faulty and not taking place as required. This is externally manifested by way of a disease.

The natural corollary of this would be that correction in the defective make up of the gene would automatically lead to normal functioning of the body. The current motto is ‘To repair what you can and replace all that what you cannot repair’. This is now being taken care of by the break through in stem cell research and gene therapy. The repair and replacement therapy is taken care of by way of stem cell and gene therapy. It is aimed to restore the original functions and restore back to the disease-free state.

• Stem cells are primarily taken up because they are still at the threshold of adolescence. They are active, vigorous and have the potential of being transformed into mature cells of the desired type such as the nerve cell, blood or any other tissue. The acquire forms similar to the neighboring cells in whose vicinity they fall.

• Practically this is undertaken by first boosting the production of stem cells in the bone marrow and in the connective tissue around blood vessels of the umbilical cord and the placenta. These stem cells are harvested and then injected in the organ that requires the repair. For example stem cells from the bone marrow after harvesting are injected into failing heart helps replenish its lost properties. Stem cells have helped in curing leukemia, Parkinson’s disease, lymphoma, cancers and other rare ailments.

• Another repair and replacement technique is the gene therapy. Genetics have learnt to cut, splice and insert genes using the genetic scissors and genetic glue. Genetic scissors are the enzyme endonuclease and glue is the enzyme ligase which is capable of artificial synthesis in the laboratory.

• The defective gene is cut using endonuclease and removed. Simultaneously the counterpart gene functioning normally is extracted in the similar fashion from another organism particularly from bacterium E.coli. The normal gene is inserted in the diseased organ and fixed using ligase. Soon the normal gene is integrated in the genome which now behaves as normal. The major bonus with this technology is that the incurable genetic disease being transcending hereditarily is cured for ever. The next generation will receive the customary gene and shall be disease free.

• Gene replacement has helped cure diabetes, color blindness, severe combined immunodeficiency (SCID), cosmic enhancement, anti-aging and several such times programmed by genetic coding and timing. Gene and stem cell therapy are the modern elixirs to eternal youth and facilitators to a disease free-ageless body.

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Mike Martinez asked:


We hear much controversy concerning the ethical nature of Stem Cell reasearch. In particular embryonic stem cells. The reason is clear, embryonic stem cells are taken from a developing embryo, thus destroying it.
Yet Stem Cell research continues because they have shown to have the potential to develop or transform themselves in almost any cell in the human body. This means a rejuvenation of damaged or injured organs. Many of todays so called degenerative diseases, which we currently have little if any effective therapies, could in fact be alleviated or healed. Advocates of Stem Cell research argue that Stem Cells could hold the key to curing diseases like cancer, AIDS, Alzheimer and multiple sclerosis, just to name a few. Facinating science.

However what most people have not heard about is Adult Stem Cells. These Stem Cells are found in the human body, mainly in the bone marrow. Recent research shows that Adult Stem Cells also have the ability to renew damaged organs and tissue within the body.

In fact, while embryonic Stem Cells have not been used in even one human therapy, Adult Stem Cells have already been used successfully in numerous patients. Jay Lefkowitz, a former adviser to President Bush on Stem Cell policy says, “Adult Stem cells are really where the real progress is being made.”

The key difference with Stem Cells is that they can divide, regenerate and actually become different organ cells. Research has conclusively shown Stem Cells can become liver cells, blood cells, pancrea cells, heart cells, and even brain cells. Almost any cell or tissue in the body.

For decades now Adult Stem Cells have been used very successfully in bone marrow transplants to treat certain cases of blood disorders and leukemia. A massive amount of research, which is still in it’s early stage but none the less very promising, shows impressive results for heart damage due to heart attacks, liver disease, bone and cartilage diseases and brain disorders.

In a landmark experiment, Professor Saul J. Sharkis of John Hopkins University was able to convert bone-marrow Adult Stem Cells from animal donors into healthy liver cells. He says, “It is mind blowing stuff. I never would have thought this would be possible.”

In another landmark experiment carried out by scientist at Yale University in 2001, Adult Stem Cells taken from the bone marrow of male mice were injected into female mice whose own marrow was destroyed by radiation irradation. Eleven months later, the male stem cells (identified through the Y chromosome) were found not only in the females’ bone marrow, but also in their blood, guts, lungs and skin tissue.

While there is still much to learn about the magic of Adult Stem Cells, we can rest assure that a breakthrough in health is right around the corner.

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Maria Leonora Albino asked:


More than same-sex marriage and pedophile priests molesting choir boys, what tears the Christian Church apart is its own followers’ biases and prejudices against each other.

As Christians, we tend to focus too much on our diversity that we forget what it is that unites us: our faith in Jesus Christ, his death for sins, burial, resurrection and our desire to follow His teachings.

But is it possible to have unity in the Christian Church? The answer is yes. Love, understanding and praying for unity are what we need to break down denominational walls in the Church.

With two billion followers, Christianity is the world’s most widely practiced religion. If a family consisting of a father, a mother and their two children may not always see eye to eye, how much more such a huge number of people? Dissension cannot be avoided and there will always be disagreements. It is when we begin to ask, “Whose views are more superior?” that judgment starts. This leads to alienation, and alienation is what creates disunity among us.

Wracked by issues as child sexual molestation by the clergy, contraception, abortion, stem cell research and divorce, the moral authority of the Christian Church is continuously under scrutiny. Also, some denominations within the Christian Church openly support homosexuality and gay marriage even among male priests and consecration of openly gay bishops. This triggers denouncement from other Christian groups which perceive these practices as blasphemous to the Church’s doctrines and damaging to the already fragile image of the Christian faith.  

Another issue that has drawn criticisms from both Christians and non-Christians alike is the growing number of churches being established in areas in close proximity of each other. One example of this is a particular town in Texas which only has a population of around 20,000 but 51 churches were built in the area. It seems the Christian Church is taking the words, “Go forth and multiply” too literally. With the problems hounding it, it seems that the Church’s response is to build more churches much like social networking sites sprouting on the internet instead of unifying the members of the existing ones.

Instead of addressing these glaring problems within the organization, church leaders hurl blame against each other. Different denominations preoccupy themselves arguing about non-essential matters like worship styles, Arminianism, Calvinism, etc., instead of uniting on the foundation of Christianity. This somehow proves what most people fear all along, that the Christian Church is the Church of the Disunited.

How can the Christian Church summon enough credibility (and focus as obviously its energies are scattered) to continue to preach the word of God? How can it defend itself from the attacks of other religions when a war is raging within the Church itself? Division and bickering is like a disease that attacks the Christian Church from within, much like an auto immune disease.  

How differences can be healthy

A little dose of differences among the members of the Christian Church can be healthy because it leads to dynamism. “For there must also be factions among you, in order that those who are approved may have become evident among you,”(1 Cor. 11:19). 

According to Romans 14:1-12, we may have differing opinions, but we should not judge each other because “To his own master he stands or falls; and stand he will, for the Lord is able to make him stand.  One man regards one day above another, another regards every day alike. Let each man be fully convinced in his own mind…” God himself will be the judge.  

Not one denomination of the Christian Church should consider itself superior and regard the other groups with contempt. Christians may operate under different names, but it should not matter because God gave us no name but his under which to rally.

Unity in the Christian Church is possible

Unity is not achieved by ramming one’s opinions down someone else’s throat and the other person blindly conforming to these. We need to recognize that our differences of opinions and worship styles are fine, but we need to constantly work and pray for unity.  

What is important is for us to practice God’s loving and accepting attitude across denominational barriers. When we reject others whom Christ has accepted, it conflicts with the very nature of the Christian faith which preaches about love, forgiveness, self sacrifice, humility, and unity. What God truly meant for us to do is to practice His teachings and spread His word, not sit as judge of the other person.

Would it not be a good way to preach to the world about Christianity if the Christian Church is able to unite despite its differences? Would it not please God if Christians, regardless of denominations, are able to accept and love each other?

Love, acceptance, and praying for unity

Love, acceptance, and praying for unity are the perfect unifying bond for the Christian Church, and these should be tightly woven into the spiritual and moral fiber of the Christian faith. The unity of the Christian Church begins with individuals praying for unity. 

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Lawrence Ebert asked:


In March 2006, there was renewed concern about the patent system, manifested not only in discussion of the NTP v. RIM (BlackBerry) case, which settled for $612.5 million but also on the fate of the use of injunctions in patent infringement cases, to be reviewed by the Supreme Court in eBay v. MercExchange. The Wall Street Journal wrote that U.S. patent law is “deterring research and penalizing innovation,” and that the patent system is “fast becoming a detriment to U.S. competitiveness, not to mention basic fairness.” The idea that patents are not central to innovation can also be found in the philosophy of some venture capitalists, who will directly tell you “patents are not why we are investing.”

Although some people, such as Adam B. Jaffe, and Josh Lerner, suggest the patent problems are of recent origin, with changes in the last 20 years which have led to a decline in patent quality but a strengthening in patent rights, the empirical evidence for this is thin. Many of the issues we see now have been around for a long time.

In the following, aspects in the history of the light bulb are discussed. Consistent with the viewpoint of the VCs, J.P. Morgan invested in Edison, the man, before Edison’s key patent
issued. To attract attention of the influential, Edison set up the first commercial electric power plant near Wall Street, much as RIM (BlackBerry) has attained impact through the opulence of
its customers. After a commercial beachhead was established, the patent wars began. Edison’s final success in the patent wars was established both offensively and defensively, and was greatly
assisted by his high profile. It is suggested that certain legal issues that confronted Thomas Edison in the 19th century will soon appear before stem cell workers in the 21st century. [Of various suggestions that Edison was troll-like in his behavior in not making product, one observes that Edison himself obtained the funds from investors to set up the first electric power plant, and then created the power plant. He made product. Whether he was actually the inventor of the light bulb is a different story.]

DID EDISON INVENT THE LIGHT BULB?

Although not widely discussed, the application for Edison’s famous US Patent No. No. 223,898, granted January 27, 1880, was involved in an interference with competing inventors Sawyer and
Man and Edison lost on the contested point.

Following up, the successors to Sawyer and Man challenged Edison’s patent. The basic claim of Edison read: An electric lamp for giving light by incandescence, consisting of a filament of carbon of high resistance, made as described, and secured to metallic wires, as set forth. The trial court noted that Edison “was the first to make a carbon of materials and by a process which was especially designed to impart high specific resistance to it; the first to make a carbon in the special form for the special purpose of imparting to it high total resistance; and the first to combine such a burner with the necessary adjuncts of lamp construction to prevent its disintegration and give it sufficiently long life.” The trial court also noted, somewhat
cryptically, “There are many adjudicated cases in which it appears that the inventor builded better than he knew; where a patent has been sustained for an invention the full significance of which was not appreciated by the inventor when it was made. In the case of the Bell telephone patent there was great room for doubt whether the speaking telephone had been thought of by Mr. Bell when he filed his application for a patent, but the court said: ‘It describes apparatus which was an articulating telephone, whether Bell knew it or not.’” Edison’s patent survived. A problem with the court’s analysis is that the distinctly long life of Edison’s filaments arose from the use of
bamboo, which was not disclosed in Edison’s patent.

In a case that went all the way to the Supreme Court, the relevant patent of Sawyer and Man, asserted against the interests of Edison, did not survive. The first claim of U.S. Patent No.
317,076 (related to patent 205,144 ) read: An incandescing conductor for an electric lamp, of carbonized fibrous or textile material and of an arch or horseshoe shape, substantially as
hereinbefore set forth. The Supreme Court noted: “It is admitted that the lamp described in the Sawyer and Man patent is no longer in use, and was never a commercial success; that it does not
embody the principle of high resistance with a small illuminating surface.” Getting to the broadness of the Sawyer/Man claim, the Supreme Court stated: “But if woods generally were not adapted to the purpose, and yet the patentee had discovered a wood ossessing certain qualities, which gave it a peculiar fitness for such purpose, it would not constitute an infringement for another to discover and use a different kind of wood, which was found to contain similar or superior qualities.” The court further noted that Sawyer/Man “made a broad claim for every fibrous or textile material, when in fact an examination of over six thousand vegetable growths showed that none of them possessed the peculiar qualities that fitted them for that purpose. Was everybody then precluded by this broad claim from making further investigation? We think not.”

The court noted that Edison “found suitable for his purpose only about three species of bamboo.” After discussing the amount of work Edison did with bamboo, the court asked: The question
really is whether the imperfectly successful experiments of Sawyer and Man, with carbonized paper and wood carbon, conceding all that is claimed for them, authorize them to put under
tribute the results of the brilliant discoveries made by others.”The court brought up the “infringement if later, anticipation if earlier” argument: “if the patent were infringed by the use of any such material, it would be anticipated by proof of the prior use of any such material.”

Although the Supreme Court did not address the issue, there were allegations by Edison at trial that Sawyer/Man had amended their application to conform to Edison’s work: “no such invention
was set forth in the original application, but was introduced for the first time more than four years after it was filed, and after the same material had been used by Edison, and claimed by
him in an application for a patent.” The trial court agreed, saying “after Edison’s inventions on this subject had been published to the world, there was an entire change of base on the part of Sawyer and Man, and that the application was amended to give it an entirely different direction and purpose from what it had in its original form …. [Testimony] shows that the idea of claiming carbons made from fibrous and textile materials was an after-thought, and was no part of the purpose of the original application.”

Of the issue of inventorship, text within the court cases manifests diffidence as to whether Edison was, or was, not the inventor of the light bulb. In 1875, Henry Woodward and Matthew
Evans patented a light bulb, the rights for which were purchased by Edison. In 1878, Joseph Wilson Swan invented a light bulb whose lifetime was about 13.5 hours. Edison’s bulbs in 1880, derived using a filament derived from bamboo, lasted 1200 hours.

The issues in the 1895 case are not unrelated to those in LizardTech v. Earth Resource Mapping, 433 F.3d 1373; 2006 U.S. App. LEXIS 137; 77 U.S.P.Q.2D 1391 (CAFC 2006) and are not
unrelated to issues in the current discussion of alterations in the practice of continuing applications.

[Endnote 13, which appears here in the text, states: 71 Fed. Reg. 48 (Jan. 3, 2006). Abuses of applicants while awaiting developments in similar or parallel technology caused by amending the pending application to cover developments. If the
amendments are covered by the disclosure, this practice is allowed. PIN/NIP, 304 F.3d 1235.]

STEM CELLS

The situation faced by the courts in the 1880′s, in trying to figure out who made the step-out invention with the light bulb, will soon be faced by the courts of the 21st century, in trying to figure out who has made the step-out invention in embryonic stem cells. Although there are presently numerous patent applications on somatic cell nuclear transfer [SCNT] in various phases of generating embryonic stem cells, there are presently questions of scope of invention and of enablement, just as there were in the 19th century. Although many people are now claiming
large, with perhaps limited enablement and written description, the ultimate winner will be the person, who both identifies the insight to make the entire system happen and obtains patent
protection thereon.

UPDATE TO “YOU ONLY LOOK TWICE”

In the November 2005 issue of Intellectual Property Today, I presented some data on continuing applications for FY 2004 from the PTO, and noted the USPTO is evaluating the possibility
of limiting continuations, which crystallized in the Federal Register in January 2006. Two readers from Chicago, Kevin Noonan and Paul Reinfelds, sent along data for FY 2005, and noted, with the small number of “second” continuing applications, that the PTO proposal limiting continuing applications, even if effected, would not likely solve the problem faced by the PTO.

[Endnote 18 stated of the data for FY 2005: There were 63,000 continuing applications, which included 44,500 cons/cips and 18,500 divisionals. Of these, 11,800 were second, or subsequent, applications. Separately, there were 52,000 RCEs, of which 10,000 were second, or subsequent. Thus, 21,800 applications of
384,228, were second or subsequent, which is 5.7%. As for FY2004, RCEs were the single most abundant “continuing” form, 52,000 of 384,228 [13.5%]. All “continuing” forms combined
constituted 115,000 of 384,228 [30%]. The contents of Endnote 18 were cited in comments made to the USPTO about proposed rulemaking in the area of continuing applications:
www.uspto.gov/web/offices/pac/dapp/opla/comments/fpp_continuation/ebert.pdf.
The comments referred to my April 2006 article in Intellectual Property Today, which unknown to me at the time of the comments, was not actually published by Intellectual Property Today. These comments to the USPTO objected to the proposed limitations on second, and subsequent, continuing applications on the basis that, even if implemented, the proposed limitations would NOT resolve the application backlog problem AND separately would adversely impact many reasonable uses of continuing application practice.]

Of Carhart’s book, “Lost Triumph,” the publisher is Putnam, not Putman. Two other reviewers have discussed the novelty of the book, even though the theory about J.E.B. Stuart’s possible
role had been published years before Carhart’s book.

[After March 2006, the Supreme Court decided the case eBay v. MercExchange. Therein, the Supreme Court made clear that entities such as universities and individual inventors, who don't make product, could satisfy the four-factor test and obtain permanent injunctions to bar infringement of their patents.]

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Nick Oliva asked:


Yvonne Perry is a fellow writer and friend and after having read her book I am forwarding this information to all that I know in the hopes that they read and understand that we here in the United States are being misled as to what researchers want to use for stem cells that are not human embryos as has been misstated over and over by groups that do not want to educate themselves.

I have diabetes, without this research I will die prematurely no matter what steps I can take now. My mother died at age 67, my brothers have it and millions of others in this country need a cure, NOW! Yvonne explains that the clump of cells called blastocysts are not living human entities. If you have family, friends, or loved ones that have life threatening diseases you need to read how close we are to curing these problems if our government would stop being pressured by special interest groups that have it all wrong. There is a forward by Rev. Dan Bloodworth a strong supporter of Yvonne’s, with a Biblical Perspective on stem cell research.
Anything you can or are willing to do to help people understand the importance of federal funding for all types of stem cell research is much appreciated—especially by those who currently suffer with an illness or condition that might be helped by the derived technology and treatments.

I have read Yvonne’s book “Right to Recover” and the following is my comment on this courageous work.

Yvonne Perry has taken a courageous stand by tackling and dissecting these issues without prejudicial preconceived emotion. The biggest obstacle to this research is the inclusion of religious aspects in the determination that a blastocyst or a pile of benign cells constitutes human life, a grave error of thought. After all, is there a ceremony or last rites given to these cells? They are not inside a woman’s uterus, they have not been given DNA to substantiate they are human and can take the form of whatever host they are merged into. I am a diabetic. I will die along with millions of others prematurely. With one injection of stem cells, in the near future my pancreas could grow back and I would be able to stop shooting insulin and going into insulin shock wearing my organs down and live a normal life. All I need is the ability of these dedicated researchers to be allowed to use funding to further the research to make it all happen for millions of us. Read the book before you go off about the “point that life begins” and begin to understand how much damage is being done because of a lack of understanding of that very question.

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Breast Cancer The Cure

Feb 11, 2010
Gerald Armstrong asked:


You have my permission to publish this article electronically or in print, free of charge, as long as the bylines are included. A courtesy copy of your publication would be appreciated.

Breast Cancer The Cure

There is no known cure for breast cancer. More than 1.5 million people will be diagnosed with breast cancer this year worldwide. Scientists don’t know why most women get breast cancer, yet breast cancer is the most frequent tumor found in women the world over. A woman who dies of breast cancer is robbed of an average of nearly 20 years of her life. Breast cancer knows no social boundaries. It’s a disease that can affect anyone. Some prominent women who’s lives that have been touched by breast cancer include Jill Eikenberry actress age 52; Peggy Fleming age 49 figure skater; Kate Jackson age 50 (Charlies Angels); Olivia Newton-John age 50 actress singer; Nancy Reagan age 77 former first lady; Melissa Etheridge age 43 singer; and the beautiful Suzanne Summers actress. These high rates of breast cancer are not acceptable to the women of the world and must be met with scientific research that provides results.

Despite over a decade of research, and more than $1.7 billion spent, hundereds of women worldwide are dying from breast cancer every day. Yet doctors don’t know how breast cancer starts or how to cure it. Doctors are still approaching treatment for breast cancer in the same old fashioned ways: surgery, radiation, and chemotherapy. Barbarick treatments…And scientists keep doing the same old redundant research that’s simply not working. It doesn’t have to be that way. Gen Cells Cures is a scientific biotechnology company that is focused on a cure for breast cancer. The company is dedicated to curing breast cancer before it’s too late for you. We’re not interested in a cure in five, ten, or twenty years from now. We want your cure for breast cancer within a year or two. We don’t want you to have to under go surgery, radiation, chemotherapy or take toxic drugs.

Why Gen Cells Cures? You can search the medical journals; you can search the internet until your blue in the face. You will find the same old news which is no new news about breast cancer research and treatments. Breast cancer research is locked up in a black whole. Gen Cells Cures is approaching the cure for breast cancer from different angles and using tomorrow’s scientific technologies today. Our expertise is in stem cell research and genomics. Malfunctioning stem cells have already been linked to the development of breast cancer. We’re not talking about using generic stem cells from an egg and sperm cell. There is no genetic match for you with the politically controversial generic stem cells that are always in the news. The isolation of cancer stem cells, coupled with our understanding of genetic mutations causing cancer, and our knowledge of genomics will result in ways to eliminate cancer cells while sparing normal breast tissues.

Genetics and Breast Cancer

People will tell you to accept what you can’t change…Your genetics, your genes, the genes your mother and father handed you when you were born that came with their particular genetic make-up. Most inherited cases of breast cancer have been associated with two genes: BRCA1 and BRCA2. The past five years has been a period of unparalleled discovery in the field of genetics, genomics, and stem cell research, but these discoveries are not being applied to breast cancer treatments. A job that Gen Cells Cures definitely wants to get our hands dirty in. Recently researchers have found that by blocking a gene called beta1-integrin the growth of tumor cells can be stopped. When this gene was removed the tumor cells quit growing. You don’t have to accept the genes that you were given at birth. Gen Cells Cures will be able to manipulate your genes to cure your breast cancer.

Our Cancer Stem Cell and Genomics Program will bring together the top scientific minds in the world under one tin roof to maximize the use of diverse approaches to the understanding of cancer genomics fused with stem cell solutions. Gen Cells Cures isn’t looking for a multi-million dollar biomedical research center like the Stowers Institute in Kansas City, which is a medical center to be admired. A rented tin shack will do just fine. Of course, we would accept hand-me down michroscopes from the Stoweres (billionaires who bought their own multi-million dollar biomedical research center) if they would be gracious enough to grant them to us or we would accept a small prime the pump check to move forward with our research. The Stowerses and all the scientists from the Stowers Institute have an open invitation to visit our lab in the Caribbean. What we are looking for is a cure for breast cancer to stop the humiliation, pain and suffering this menace to society causes millions of women and thousands of men worldwide, and not a new biomedical center… Every dollar invested with us goes into pure medical research and equipment. The same offer goes out to all the millionaires and especially the billionaires of the world. People that come to mind are: Paul Allen, Bill and Melinda Gates, Jon Huntsman, William and Alice Goodman, Ann Lurie, Jamie and Karen Moyer, Harold C. Simmons, Alfred Mann, Sumner M. Redstone, Michael Milton and the Palm beach billionaires, there are simply too many to mention. The combined wealth of the three Microsoft billionaires alone is more than ten times the amount spent by the U.S. Federal Government on research to fight cancer and other deadly diseases. We know we’re in the wrong business to become billionaires ourselves. This kind of biotechnology has never produced even one billionaire. It’s the cure for breast cancer that we want.

Simply put the cancer research organizations are funding the wrong researchers. It’s time to go outside the normal research channels. Do something different. The same story year after year after year and no cure. These unmotivated researchers just aren’t getting results. Let someone else have a shot at it. It’s time to try something new and different. A different approach. There are races for the cure, golf tournaments for the cure, there are walks for the cure, there are foundations for the cure. These foundations have been funding the same ineffective research for more than twenty years now. These foundations have been betting on the wrong horse. Joining the crusade won’t help if the research being done doesn’t take on a twenty-first century scientific approach. It’s been time to move forward scientifically for five years now. But today’s breast cancer researchers are stuck in a twentieth century mind-set. The Excuse is someday we’ll find the cure, but someday doesn’t help today’s victims of breast cancer. We need top notch scientific action today.

The genetics are out of the bottle and stem cell research is moving forward whether the U.S. government likes it or not. Gen Cells Cures has moved off-shore to the Caribbean to avoid the political controversy over stem cell research. I am sure you won’t mind a walk on the beach with me to talk about your cure for your breast cancer. Once we have the cure we can take the cure from the bench to the patient without a long and costly wait for FDA approval. There are many advantages to not having big brother breathing down your neck. The governments of the United States and Western countries have nothing to offer except road blocks, red tape and detours. Our patients don’t have time for political smoke and mirrors. With a little luck we could have your cure before the time comes that you need that dreaded surgery and chemo.

Our gifted world-class researchers are visionary and have been schooled in winning and have courage, creativity, can-do attitudes, burning desires, unfaltering belief and an obsession that they will be there first. By first we mean years ahead of the other biotechnology companies. Like determined, fighting NASCAR drivers our scientists are living to take the chequered flag of biotech and win the coveted race for the cure for breast cancer.

Focused on breakthrough discoveries, Gen Cells Cures nurtures a culture that encourages high standards of excellence, original thinking, hard work and a willingness to take risks. Our world-renowned scientists believe in themselves and its belief that gets us there. The company will seek to develop a work environment that is results focused and team-orientated. We compete against time. Though we compete intensely we maintain high ethical standards and trust and respect for each other. Quality is the cornerstone of all our activities. We seek the highest quality information, decisions and people. Our success depends on superior scientific innovation. We see the scientific method as a multi-step process which includes designing the right experiment, collecting and analyzing data and rational decision making. It is not subjective or emotional but rather a logical, open and rational process.

Our success comes from one simple fact; we are committed to being a science-based, patient-driven company, driven by that one special breast cancer patient…you.

Gen Cells Cures lost most of our one million dollar start-up money in offshore bank scandal and currency devaluation last year. We are now actively pursuing financial support. Unfortunately, the Gen Cells Cures team is made up of great scientific minds and not great marketers, salesmen, or fund raisers. Yes, we are looking for a millionaire or billionaire without a cause to support our work, but if you are not our wealthy saviour, we welcome any help, be it financial or a donation of your time. The scientific team is on stand-by. What we’re lacking is the funding to go forward. We could use motivated salesmen to sell our research, fund raisers, skilled internet marketers or someone just to pass out flyers or mail out promotional material. We could use help from the media with publicity stories, ads and promotions to get the word out. We are particularly interested in looking for assistance from the billionaires of the world; there are approximately 600 in the world. Billionaires like Sergey Brin and Larry Page (Google billionaires), Rupert Murdoch, Ted Turner, and Oprah Winfrey and others who control the media could get our life-saving message to the world fast. We are also hoping that some of my celebrities friends will come forward and spread their wings to help support our breast cancer research: Steven Seagal, Charlie Sheen, Wesley Snipes, Danny Glover, Erik Estrada, Tom Arnold, Dolph Lundgren, Roger Clinton, Bill Clinton, Usher, Hulk Hogan, Ivana Trump, John Secada, Sylvester Stalone, Arnold Schwarzenegger, Mike Reno, Richard Branson, Cindy Crawford, Cher, Demi Moore, Michelle Pfeiffer, and other stars that I have had the good fortune of meeting in person and others celebrities that I hope to meet in the future. (Photos of Gerald and the stars can be viewed at his promotional group listed below.) I am waiting to get my photo with Suzanne Summers!

Gen Cells Cure offers more than hope. We can do the job. If you’re going to eradicate cancer you have to have the right people doing the right research. One thing is for sure. We couldn’t do any worse than what the scientists before us have done. Which is virtually nothing! Help us alleviate the pain and suffering. Together, with your help, we can cure breast cancer.

Article by Gerald Armstrong- scientist0707@yahoo.com
Gerald is the owner of Gen Cells Cures
Visit his group for information about “The Cure” for incurable diseases and aging.

Group address http://www.msnusers.com/cures

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Yvonne Perry asked:


There’s a big buzz in the scientific community because President-elect Barack Obama plans to issue an executive order allowing federal funding for blastocystic stem cell research on cell created after 2001.

In an article by Reuters on February 15, 2009, a reporter indicated that stem cells come from cells that must be extracted from human embryos. That implies that these cells are being taken from the womb, and this is simply not true. These cell clusters are cultivated and stored in a laboratory, not in a woman’s body.

Federal funding will not destroy any embryos. The cells used by scientists come from blastocysts leftover from in vitro fertilization. Those cells would have been disposed of anyway, unless they are adopted by another couple! The freezer life of these cells are not eternal, so while we are waiting for a reversal, a decision is being made. We have decided that these cells are better off in the trash than they would be if used for research that could help millions of living human beings. A sad commentary for all of us-especially conservatives who consider themselves as pro-life. Allowing sick and injured people to die does not save babies or blastocysts.

The Bush Administration did not ban research on all blastocyst cells. In 2001, President George Bush hampered stem cell research by restricting government funding on embryonic stem cell research to the stem cell lines created prior to April 2001. Therefore, Bush is not a hero for saving poor little embryos that were on the chopping block. Those cells are still being discarded. Instead, he delayed research that could have advanced science to a point where we could have seen cures for many illnesses by now.

Blastocysts created prior to 2001 used old technology cultivated with mouse feeder cells and only represent a limited cross-section of the population. Newer technology without mouse cells is easier to work with and represents better diversity. Obama’s reversal of Bush’s veto will still mean we are eight years behind schedule, and that people have had to suffer (and die) for a religious cause based on a misinformed opinion rather than scientific fact.

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Brooke Ellison asked:


The complex field of stem cell research is expanding at a remarkable rate, but public understanding of this topic is still growing. With so much information to be learned, and equally as much information available, it can be difficult to find legitimate and localized sources. Our goal is to make this information easily accessible and understandable so you, too, can be on the forefront of this cutting edge research.

One of the most basic questions in this research is two-fold: What are stem cells and where do they come from? Stem cells, like other types of cells, are found throughout the body, but they have two very unique characteristics. 1) they have the ability to divide into other types of cells and 2) they can replicate themselves for long amounts of time. So what exactly does that mean?

If we go back to the basics, all of our organs, in all parts of our body, are made of cells. In fact, there are over 200 different types of cells in the human body. There are cells that make up our skin, our bones, our blood… everything. While ordinary cells divide to create a copy of themselves, what makes stem cells so unique is their ability to divide into all of the 200+ types of cells as well as a copy of themselves.

Even though these cells can be found throughout the body, there are specific places where they are localized, and they are therefore named based on their organ of origin. Embryonic stem cells (es cells) are the type that has generated the most attention and controversy, but also the most excitement. Once an egg has been fertilized, it goes through a very rapid division process. After about three days, the structure that started as one cell, has divided into a structure of about 100 cells, called a blastocyst. A blastocyst looks almost like a microscopic version of a walnut, with a diameter less than that of a strand of human hair. Es cells are obtained by extracting the “inner cell mass” from the inside of the blastocyst. These cells are then placed in culture, which allows them to divide and replicate. They are described as pluripotent, meaning they can replicate themselves infinitely and have the unique ability to be coaxed into differentiating into all types of cells in the human body.

A common misconception is the idea that es cells come from fetuses or babies. As previously described, es cells come from a blastocyst, which is neither a fetus nor a baby; a blastocyst it is an early-stage embryo. The controversy surrounding embryonic stem cells centers on the ethical question as to when a human life begins, however a vast majority of individuals don’t attribute the same moral status to this blastocyst as to a living human.

The other major type of stem cell is collectively called adult stem cells, which are found in various locations throughout the human body, as well as in umbilical cord blood. These adult stem cells can be classified further depending on where in the body they come from. For instance, cardiac stem cells were recently discovered in the heart and neural stem cells are found in the nervous system. What makes adult stem cells different from embryonic is that they are multipotent, in that they can arguably only differentiate into a limited number of cell types, notably cells from which they were originally extracted. Adult stem cells have been in use for several decades, however largely only to treat blood disorders, as many of these have been found in bone marrow where blood is made. On the other hand, as discussed, es cells have the unique ability to differentiate into any kind of cell type, highlighting their vast potential in treating disease and becoming cell replacements.

Recently, new technological advances have opened up the possibility to create embryonic and embryonic-like stem cells through processes called somatic cell nuclear transfer (SCNT) and cellular reprogramming (IPS). The results highlight the exciting and dynamic nature of this field. At the same time though, they all offer something unique and must be studied together in order to find cures and treatments to disease.

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Mia Savarino asked:


Plastic surgeons and their patients have personally witnessed the benefits of utilizing adult stem cells in their procedures. The Obama Administration’s recent reversal of eight years of stem cell research restrictions points to revolutionary era of medical innovation.

Many people do not realize that stem cells have been utilized in plastic surgery for decades now. Fat carries a good number of adult stem cells which have been utilized in modern plastic surgery procedures such as fat grafting, fat transfers and fat injections. Patients who receive fat injections from me look unbelievably younger in their one year follow-up. The reason is, the stem cells in the fat injections bond with the patient’s tissues in their face, adding to lost bone and muscle tissue while improving the quality of the skin.

With the Obama Administration embracing and allowing further research into this revolutionary medical technology, the sky is now the limit. The recent lift of stem cell research restrictions by President Barack Obama has been heralded by stem cell researchers across the nation. The action has reversed an eight year research ban and, to many, signifies the coming of a new era of potential cures for many debilitating diseases like diabetes, Parkinson’s, Alzheimer’s and many cancers. Among the advocates for stem cell research and technology are plastic surgeons who have seen the benefits of stem cell use first hand.

Stem cells are special cells that have the ability to become other types of cells, like skin, bone, nerve, or muscle tissues. Embryonic stem cells are the most well-known and controversial type. But there are other stem cells in the body called adult stem cells. Fat transfers and fat injections involve harvesting fat, sometimes called adipose tissue, from unwanted areas of the patient’s body. This harvested tissue is then injected into areas of the face to fill in wrinkles and areas that typically lose tissue mass as a result of aging. This method of injecting filler is often considered safer than other methods because the patient’s own tissue is being used.

Surgeons noticed unexpected benefits in their fat transfer patients. In Europe, surgeons process the fat to get a high concentration of stem cells. This supercharged stem cell fat is then used to rejuvenate the skin and the face. Fat stem cells have even been used in reconstructive plastic surgery. In 2004, surgeons in Germany used stems cells from fat tissue of a seven year old girl to help repair major damage to her skull. The large hole in the skull is now replaced by solid bone. In 2006, researchers in UCLA announced successfully transforming adult fat stem cells into smooth muscle cells, which help the normal function of a large number of organs like the intestine, bladder and arteries.

Since 2004, The Patients Advantage is fast becoming the largest matchmaker of board-certified plastic surgeons in the world and is recognized as a leading information source on cosmetic and reconstructive plastic surgery – matching over 9,000 people with plastic surgeons.

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Sowjanya S asked:


Suddenly, stem cells are everywhere. Once referred to mostly in health journals, these microscopic clusters have made their way into news, research reports, business reports etc. The complexity surrounding these relatively simple cells has increased every second.

Recent studies suggest these cells may hold the secret to treatment, even cures for some of our most inexplicable diseases, including Alzheimer’s and Parkinson’s.

Embryonic stem cells are controversial. They come from the inner cell mass of a blastocyst (term for a fertilized egg). At the heart of the stem cell debate is a battle – over abortion as, these are cells from embryos. According to the religious orthodoxy, an embryo is life. But these cells also hold great promise for millions of ailing patients and their families. Moreover, many of the embryos would otherwise be unceremoniously discarded.

Until very recently, the vast majority of stem cells used in research came from discarded (or excess) embryos stored at in-vitro fertilization clinics. If potential parents decide against having more children, scientists working with stem cells might ask them to consider donating the unneeded embryos to research.

Adult stem cells taken from the blood or organs of healthy adults have recently demonstrated an unexpected adaptability in lab experiments. But these cells are marginally helpful to scientists, and do not show the same promise as those culled from embryos. Adult cells are fairly set in their ways, and don’t seem to grow or replicate themselves as quickly as their younger counterparts.

New techniques for gathering the cells are in quiet development; scientists are generally wary of disclosure, because public reaction is difficult to predict. Revelations that scientists at a privately-funded fertility clinic are growing human embryos with the intent of harvesting stem cells have provoked widespread hand-wringing, among both advocates and opponents of stem cell research. Advocates worry that publicizing such a blatant and systematic cell harvesting procedure can only harden hearts against the science; in the crude terms of public relations, using stem cells from discarded embryos is one thing, but purposefully creating an embryo only to dismantle it is something else altogether. Opponents of the research see the clinic’s methodology as the best indication yet that we are carelessly sliding down the slippery slope of destroying human life in order to advance our scientific curiosity.

www.BrandPrinciples.com

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Don Margolis asked:


Wales native, Michael Epps was just a normal 21 year old, playing soccer everyday while working in a warehouse. In 2007, unfortunately, for no apparent reason, Michael started suffering from horrible pains throughout his body. The doctors examined him thoroughly and gave him the dreaded diagnosis of Motor Neurone Disease.

A disease that normally occurs in people over the age of 60, Epps is believed to be one of the youngest patients ever to suffer from Motor Neurone Disease. The complications of Motor Neurone Disease include muscle deterioration, loss of mobility, and the disease eventually affects the ability to breathe, speak, and swallow.

Luckily, Michael’s parents came up with a plan. After doing some stem cell research on the internet, they saw that adult stem cells were helping patients with similar conditions to Michael’s. Therefore, when Michael’s sister Rhys was born, they froze the umblicial cord stem cells extracted from the cord blood. Later on, the cord blood stem cells along with Michael went to China where a stem cell doctor implanted the matching cord blood stem cells into Michael’s spinal cord.

It took almost 6 months, but eventually Michael began to see signs of improvement. These days, although not yet 100%, Michael’s condition has stopped deteriorating and now he is actually improving. There is much more definition in his muscles and he doesn’t need a wheelchair anymore.

Michael’s doctors believed Michael would have died in March 2008 and while the future is still unknown for Michael, he has plenty of hope now and is still trying to improve his quality of life.

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Lawrence Ebert asked:


In January 2006, the journal Science retracted the 2005 paper by university professor Hwang Woo-Suk and co-workers which had proclaimed the existence of patient-specific embryonic stem cell lines. If the paper had been true, it would have suggested that tangible medical applications of embryonic stem cell might be close in time. Concerning the publication of this fraudulent paper, it is interesting to note BOTH that the referees and editors found no difficulty with the paper at submission AND that scientific experts in the embryonic stem cell field did not question the paper prior to the unraveling in December 2005. Nobody in the field could identify a fraudulent paper.

In my paper LESSONS TO BE LEARNED FROM THE HWANG MATTER: ANALYZING INNOVATION THE RIGHT WAY (88 JPTOS 239 (March 2006)), I noted that incidences of misstatements by academics in the published literature are not uncommon. For example, a Stanford University professor writing in the Stanford Law Review proclaimed that Gary Boone was the inventor of the integrated circuit. Mark A. Lemley, Patenting Nanotechnology, 58 Stan. L. Rev. 601, 612 (2005). This misstatement, ignoring the true inventors Noyce and Kilby, sailed right through the “review” process at the Stanford Law Review. Further, the “message” Lemley drew from the Boone invention of the IC was that The sum of all these stories is rather remarkable: for one reason or another, the basic building blocks of what might be called the enabling technologies of the twentieth century – including the computer, software, the Internet, and biotechnology – all ended up in the public domain. In reality, the IC is an example of a situation in which users had to pay royalties not to just one patent holder, but to two (Texas Instruments AND Fairchild).

Academic research is not the only area in which one must be wary.

Did New Jersey actually fund stem cell research?

A number of publications have suggested that the state of New Jersey was the first state to use public funds for research in embryonic stem cells:

New Jersey officials on Dec. 16, 2005 announced $5
million in grants for stem cell research, including
studies involving human embryonic stem cells. The
awards are said to be the first instance of a state
using public funds for such research.

The grants may appear to be modest compared with those
for other scientific endeavors, but they represent an
important step in New Jersey’s effort to establish a
stem cell research industry. With strong competition
already under way from California and Florida,
supporters say, New Jersey cannot afford to fall
behind.

”The grants we have awarded today are based on
science, not politics, and have been conceived by some
of the brightest minds and best institutions in our
state,” Acting Gov. Richard J. Codey said in a
statement. ”This funding will hopefully set the stage
for a new era in medical treatments that will ease the
suffering of millions and ultimately save lives.”

New York Times, B2, December 17, 2005

California’s pioneering initiative has caused a
backlash, as some states have enacted bans on publicly
funded embryonic stem cell research. Yet others —
including Connecticut, New Jersey, Texas and Illinois
– have recently approved small amounts of state
funding for research.

Los Angeles Times, B1, Feb. 27, 2006

“Californians’ decision to put out a welcome mat to embryonic stem cell research has prompted reaction among states that
don’t want to see a brain drain in biotech.
Connecticut, Massachusetts and New Jersey have passed
state laws to encourage embryonic stem cell research.”

New Jersey Law Journal, Feb. 20, 2006

At this point in time, it is not clear that both houses of the New Jersey state legislature actually approved this expenditure of money, or that actual money has gone from the state of New Jersey to research institutions for funding stem cell research.

Google uses citation hits, not accuracy, to determine ranking of hits in search engine results

People are still only willing to look at the first few tens of results. Because of this, as the collection size grows, search engines need tools that have very high precision (number of relevant documents returned, say in the top tens of results). Indeed, search engines want the notion of “relevant” to only include the very best documents since there may be tens of thousands of slightly relevant documents.

Briefly, Google, in part, assigns “rank” on its search engine results much as Science Citation Index (SCI) assigned the “value” of a scientific paper based on the number of papers who cite to it. Google assumes you will find a given webpage more valuable if others have created links to it.

–> If a human reads a web page and finds it relevant, that human might put a link to it on his or her own site.

–> The higher the number of pages that link to a given web page, the more relevant it is.

Thus was born PageRank, brought to us by a small search engine called Back-Rub that later changed its name to Google.

With Google, we have a strong goal to push more development and understanding into the academic realm. Academics love citation index, and create mutual societies of cross-citation: I’ll cite your paper if you cite mine. Although some will say this is “objective,” a more apt description is that it is “quantifiable” according to relatively simple rules.

The citation (link) graph of the web is an important resource that has largely gone unused in existing web search engines. We have created maps containing as many as 518 million of these hyperlinks, a significant sample of the total. These maps allow rapid calculation of a web page’s “PageRank”, an objective measure of its citation importance that corresponds well with people’s subjective idea of importance. Academic citation literature has been applied to the web, largely by counting citations or backlinks to a given page. This gives some approximation of a page’s importance or quality. PageRank extends this idea by not counting links from all pages equally, and by normalizing by the number of links on a page. Links from well-linked pages are better indicators of quality.

An interesting example of why Google’s ranking system is not necessarily effective was in a study of Google searches for +”patent reform” +2795, in the time period after Lamar Smith’s HR 2795 on patent reform was introduced in June 2005. Initially, Google searches seemed rather underinclusive, but at least gave hits relevant to the content of the bill. As time went on, the number of hits increased dramatically, but there was an almost selective “weeding out” of substantive hits (those which really discussed the content of HR 2795 and what it might mean) in favor of more popular hits giving only cosmetic discussion of the bill. Webpages with significant content were almost eliminated.

Of the integrated circuit theme, a Google search of +Noyce +Kilby +”integrated circuit” on April 21 produced 34,300 hits. A search of +Boone +”intgrated circuit” produced 23,300, the first two hits of the search being directed to the case:

#1. http://www.law.cornell.edu/patent/comments/96_1514.htm on the case Hyatt v. Boone

#2. http://www.ll.georgetown.edu/Federal/judicial/fed/opinions/96opinions/96-1514.html on the case

Lemley’s “Patenting Nanotechnology” was among the hits:

lawreview.stanford.edu/content/issue2/lemley.pdf

siepr.stanford.edu/programs/SST_Seminars/Patenting_Nanotechnology.pdf

Thus, Googling can lead you to the conclusion that Gary Boone invented the integrated circuit.

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