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Australian story on the 7pm project about bone marrow and stem cell transplants. How easy it is to donate and how it can save lives for people with blood cancer diseases like lymphoma, leukaemia and myeloma. Talks about related siblings and unrelated donors, genetics, techniques used and registering to donate and get listed on the registry. Features myself – Stuart Flynn and family
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Originally published in 1994, this readable and well-structured text opens with an overview of the concepts behind and advantages of blood stem cell transplants. Detailed concepts of their use are later expanded upon and critically reviewed by experts. Among the important issues discussed are hematopoietic recovery, tumor contamination and techniques used to purify stem cells. Clinical trial data follow including leukemia, lymphoma, myeloma and breast cancer. The final chapter evaluates progress
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Prof Fernando da Costa – UTM, Instituto Portugues De Oncologia, Lisbon, Portugal. Traditionally multiple myeloma patients over the age of 65 have been considered unsuitable for autologous stem cell transplants, however, some centres will treat patients up to the age of 75. Prof Fernando da Costa argues that patients over 65 should considered for transplant if clinicians have followed strict selection criteria. Patients are normally conditioned with melphalan before receiving a transplant but many older patients can not tolerate a full dose and clinicians must decide between giving a reduced dose or not offering the transplant. Prof da Costa explains why he does not believe reduced intensity conditioning is suitable for elderly patients, stresses the need for more randomised clinical trials to establish the optimal doses of conditioning drugs and summarises how to determine if a patient over the age of 65 should receive an autologous stem cell transplant.
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