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Title: President Bush signs bill creating a national cord blood program.
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Human Immunodeficiency Virus Positive Man Cured By Bone Marrow Stem Cell Transplant! How?
Who would have thought 10 years ago that there would be a cure for AIDS? Well, according to the Journal Watch: HIV/AIDS Clinical Care, February 13, 2009, a 40-year-old HIV positive male German patient with Leukemia underwent bone marrow stem cell transplantation, which completely eradicated the virus from his body, 2 years later. Removing HIV was not the main reason why the patient underwent the risky procedure, doctors at the Berlin Charité Hospital said.
The principal reason was to treat the patient for leukemia, a disease characterized by an uncontrollable increase or proliferation of malformed leukocytes and their precursors in the bone marrow and peripheral blood, caused by malignancy of the blood forming organs, National Institute of Health. Therefore, it was very unexpected to witnessed the complete absence of any HIV RNA traces, according to the doctors.
The process of transplanting healthy bone marrows into people with HIV, have been done many times before without any success of removing the virus from the body. So, one can understand why these doctors were not necessarily trying to use the procedure to cure the patient of AIDS, but instead, were trying to cure him of his leukemia problem.
Sometimes this is how a cure is achievedâby sheer accident. Well, mankind has one on its hands as we speak. One might be wondering what is so different about this bone marrow transplant and others done before it. The key ingredient is a defective version of the white blood cell protein chemokine receptor “CCR5.” This protein receptor and CXCR4 are both present on CD4 T-Cells and a few other immune system cells.
The HIV virus generally enters the white blood cell via the CCR5 receptor or the CXCR4 receptor. However, if the CCR5 or CXCR4 receptors are defective, the virus cannot access the T-Cells to infect them. HIV infections via the CXCR4 receptors are rare, but they do occur by variant strains of the virus, The Lancet, May 22nd 2002.
Our discussion will therefore focus on the CCR5 receptor. A very large percent of people have normal amounts of CCR5 receptors on their CD4 T-Cells. A few of us have limited or partial amounts while some of us have none at all. Well, in this instance, it pays to have none. People who have limited amounts of the CCR5 receptor are heterozygous for the gene that codes for it.
A gene is a small segment of a double helical DNA. The DNA itself contains two strands of nucleotides base pairs that are twisted in a spiral shape like a rope. The only difference is that there are only two strands within the DNA helix while there are several within the rope’s helix.
It is therefore a segment of this helix that is termed, the gene. It is just like cutting a small segment from a rope and examining the characteristics of that segment from the rope. In our case, we will be examining the piece of the DNA that codes for the CCR5 receptor, which is also a protein. We will find that in heterozygous individuals, only one section from one strand of the DNA codes for the defective CCR5 receptor, while the opposite section on the other strand of the DNA does not code for a defective version but codes for the normal CCR5 receptor, which facilitates easy HIV infection.
People who are homozygous in relationship to the defective genetic segment (32-bp deletion) on the DNA are therefore totally immune to the CCR5 mode of HIV infection. And if those people were ever going to get HIV, they will have to be infected with a HIV variant that strictly invades the CXCR4 receptor instead of the CCR5 receptor.
On the other hand, individuals who have normal proportions of CCR5 receptors on their CD4 T-Cells with no heterozygosity or homozygosity are 100% more susceptible to HIV infection. In fact, there are tests that can be done to determine whether or not a person is heterozygous or homozygous for the defective CCR5 gene.
The HIV positive patient who was cured by the stem cell transplant was given a stem cell that was taken from a person who was homozygous for the CCR5 deletion on his/her gene. Deletion means that the normal base pairings of the DNA segments (genes) was changed into something else that does not code for anything. It is not all segments on a DNA that codes for something useful. Therefore, this is why the CCR5 receptor does not work and is therefore defective.
Sometimes certain portions of the DNA are stop codes, blanks or codes that do not provide instructions to make any proteins. A perfect example of this is trying to build a car without a blueprint or a schematic. It does not matter how much material is available. If there is no instruction of how to build cars, there will be no cars built. Our example is the same way. The DNA and segments (gene) of the DNA are blueprints that cells use to build different proteins for the body.
The HIV positive patient in our discussion was obviously infected with the HIV strain that specifically uses the CCR5 receptor has its mode of entry into the CD4 T-cells. This patient will not be infected with HIV again unless he is exposed to an HIV variant that uses the CXCR4 mode of infection or something totally different. This scenario is very unlikely provided that the patient refrain from risky sexual behaviors.
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Maria Leonora Albino asked:
More than same-sex marriage and pedophile priests molesting choir boys, what tears the Christian Church apart is its own followers’ biases and prejudices against each other.
As Christians, we tend to focus too much on our diversity that we forget what it is that unites us: our faith in Jesus Christ, his death for sins, burial, resurrection and our desire to follow His teachings.
But is it possible to have unity in the Christian Church? The answer is yes. Love, understanding and praying for unity are what we need to break down denominational walls in the Church.
With two billion followers, Christianity is the world’s most widely practiced religion. If a family consisting of a father, a mother and their two children may not always see eye to eye, how much more such a huge number of people? Dissension cannot be avoided and there will always be disagreements. It is when we begin to ask, “Whose views are more superior?” that judgment starts. This leads to alienation, and alienation is what creates disunity among us.
Wracked by issues as child sexual molestation by the clergy, contraception, abortion, stem cell research and divorce, the moral authority of the Christian Church is continuously under scrutiny. Also, some denominations within the Christian Church openly support homosexuality and gay marriage even among male priests and consecration of openly gay bishops. This triggers denouncement from other Christian groups which perceive these practices as blasphemous to the Church’s doctrines and damaging to the already fragile image of the Christian faith.
Another issue that has drawn criticisms from both Christians and non-Christians alike is the growing number of churches being established in areas in close proximity of each other. One example of this is a particular town in Texas which only has a population of around 20,000 but 51 churches were built in the area. It seems the Christian Church is taking the words, “Go forth and multiply” too literally. With the problems hounding it, it seems that the Church’s response is to build more churches much like social networking sites sprouting on the internet instead of unifying the members of the existing ones.
Instead of addressing these glaring problems within the organization, church leaders hurl blame against each other. Different denominations preoccupy themselves arguing about non-essential matters like worship styles, Arminianism, Calvinism, etc., instead of uniting on the foundation of Christianity. This somehow proves what most people fear all along, that the Christian Church is the Church of the Disunited.
How can the Christian Church summon enough credibility (and focus as obviously its energies are scattered) to continue to preach the word of God? How can it defend itself from the attacks of other religions when a war is raging within the Church itself? Division and bickering is like a disease that attacks the Christian Church from within, much like an auto immune disease.
How differences can be healthy
A little dose of differences among the members of the Christian Church can be healthy because it leads to dynamism. “For there must also be factions among you, in order that those who are approved may have become evident among you,”(1 Cor. 11:19).
According to Romans 14:1-12, we may have differing opinions, but we should not judge each other because “To his own master he stands or falls; and stand he will, for the Lord is able to make him stand. One man regards one day above another, another regards every day alike. Let each man be fully convinced in his own mind…” God himself will be the judge.
Not one denomination of the Christian Church should consider itself superior and regard the other groups with contempt. Christians may operate under different names, but it should not matter because God gave us no name but his under which to rally.
Unity in the Christian Church is possible
Unity is not achieved by ramming one’s opinions down someone else’s throat and the other person blindly conforming to these. We need to recognize that our differences of opinions and worship styles are fine, but we need to constantly work and pray for unity.
What is important is for us to practice God’s loving and accepting attitude across denominational barriers. When we reject others whom Christ has accepted, it conflicts with the very nature of the Christian faith which preaches about love, forgiveness, self sacrifice, humility, and unity. What God truly meant for us to do is to practice His teachings and spread His word, not sit as judge of the other person.
Would it not be a good way to preach to the world about Christianity if the Christian Church is able to unite despite its differences? Would it not please God if Christians, regardless of denominations, are able to accept and love each other?
Love, acceptance, and praying for unity
Love, acceptance, and praying for unity are the perfect unifying bond for the Christian Church, and these should be tightly woven into the spiritual and moral fiber of the Christian faith. The unity of the Christian Church begins with individuals praying for unity.
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NSF awards stem cell bio-manufacturing research and education program to Georgia Tech
( Georgia Institute of Technology Research News ) The National Science Foundation has awarded million to Georgia Tech to fund a unique research program on stem cell bio-manufacturing. The program is specifically focused on developing engineering methods for stem cell production, in order to meet the anticipated demand for stem cells.
Read more on EurekAlert!
NSF Awards Stem Cell Bio-Manufacturing Research & Education Program to Georgia Tech
The National Science Foundation has awarded million to Georgia Tech to fund a unique research program on stem cell bio-manufacturing. The program is specifically focused on developing engineering methods for stem cell production, in order to meet the anticipated demand for stem cells.
Read more on Newswise

Lawrence Ebert asked:
In March 2006, there was renewed concern about the patent system, manifested not only in discussion of the NTP v. RIM (BlackBerry) case, which settled for $612.5 million but also on the fate of the use of injunctions in patent infringement cases, to be reviewed by the Supreme Court in eBay v. MercExchange. The Wall Street Journal wrote that U.S. patent law is “deterring research and penalizing innovation,” and that the patent system is “fast becoming a detriment to U.S. competitiveness, not to mention basic fairness.” The idea that patents are not central to innovation can also be found in the philosophy of some venture capitalists, who will directly tell you “patents are not why we are investing.”
Although some people, such as Adam B. Jaffe, and Josh Lerner, suggest the patent problems are of recent origin, with changes in the last 20 years which have led to a decline in patent quality but a strengthening in patent rights, the empirical evidence for this is thin. Many of the issues we see now have been around for a long time.
In the following, aspects in the history of the light bulb are discussed. Consistent with the viewpoint of the VCs, J.P. Morgan invested in Edison, the man, before Edison’s key patent
issued. To attract attention of the influential, Edison set up the first commercial electric power plant near Wall Street, much as RIM (BlackBerry) has attained impact through the opulence of
its customers. After a commercial beachhead was established, the patent wars began. Edison’s final success in the patent wars was established both offensively and defensively, and was greatly
assisted by his high profile. It is suggested that certain legal issues that confronted Thomas Edison in the 19th century will soon appear before stem cell workers in the 21st century. [Of various suggestions that Edison was troll-like in his behavior in not making product, one observes that Edison himself obtained the funds from investors to set up the first electric power plant, and then created the power plant. He made product. Whether he was actually the inventor of the light bulb is a different story.]
DID EDISON INVENT THE LIGHT BULB?
Although not widely discussed, the application for Edison’s famous US Patent No. No. 223,898, granted January 27, 1880, was involved in an interference with competing inventors Sawyer and
Man and Edison lost on the contested point.
Following up, the successors to Sawyer and Man challenged Edison’s patent. The basic claim of Edison read: An electric lamp for giving light by incandescence, consisting of a filament of carbon of high resistance, made as described, and secured to metallic wires, as set forth. The trial court noted that Edison “was the first to make a carbon of materials and by a process which was especially designed to impart high specific resistance to it; the first to make a carbon in the special form for the special purpose of imparting to it high total resistance; and the first to combine such a burner with the necessary adjuncts of lamp construction to prevent its disintegration and give it sufficiently long life.” The trial court also noted, somewhat
cryptically, “There are many adjudicated cases in which it appears that the inventor builded better than he knew; where a patent has been sustained for an invention the full significance of which was not appreciated by the inventor when it was made. In the case of the Bell telephone patent there was great room for doubt whether the speaking telephone had been thought of by Mr. Bell when he filed his application for a patent, but the court said: ‘It describes apparatus which was an articulating telephone, whether Bell knew it or not.’” Edison’s patent survived. A problem with the court’s analysis is that the distinctly long life of Edison’s filaments arose from the use of
bamboo, which was not disclosed in Edison’s patent.
In a case that went all the way to the Supreme Court, the relevant patent of Sawyer and Man, asserted against the interests of Edison, did not survive. The first claim of U.S. Patent No.
317,076 (related to patent 205,144 ) read: An incandescing conductor for an electric lamp, of carbonized fibrous or textile material and of an arch or horseshoe shape, substantially as
hereinbefore set forth. The Supreme Court noted: “It is admitted that the lamp described in the Sawyer and Man patent is no longer in use, and was never a commercial success; that it does not
embody the principle of high resistance with a small illuminating surface.” Getting to the broadness of the Sawyer/Man claim, the Supreme Court stated: “But if woods generally were not adapted to the purpose, and yet the patentee had discovered a wood ossessing certain qualities, which gave it a peculiar fitness for such purpose, it would not constitute an infringement for another to discover and use a different kind of wood, which was found to contain similar or superior qualities.” The court further noted that Sawyer/Man “made a broad claim for every fibrous or textile material, when in fact an examination of over six thousand vegetable growths showed that none of them possessed the peculiar qualities that fitted them for that purpose. Was everybody then precluded by this broad claim from making further investigation? We think not.”
The court noted that Edison “found suitable for his purpose only about three species of bamboo.” After discussing the amount of work Edison did with bamboo, the court asked: The question
really is whether the imperfectly successful experiments of Sawyer and Man, with carbonized paper and wood carbon, conceding all that is claimed for them, authorize them to put under
tribute the results of the brilliant discoveries made by others.”The court brought up the “infringement if later, anticipation if earlier” argument: “if the patent were infringed by the use of any such material, it would be anticipated by proof of the prior use of any such material.”
Although the Supreme Court did not address the issue, there were allegations by Edison at trial that Sawyer/Man had amended their application to conform to Edison’s work: “no such invention
was set forth in the original application, but was introduced for the first time more than four years after it was filed, and after the same material had been used by Edison, and claimed by
him in an application for a patent.” The trial court agreed, saying “after Edison’s inventions on this subject had been published to the world, there was an entire change of base on the part of Sawyer and Man, and that the application was amended to give it an entirely different direction and purpose from what it had in its original form …. [Testimony] shows that the idea of claiming carbons made from fibrous and textile materials was an after-thought, and was no part of the purpose of the original application.”
Of the issue of inventorship, text within the court cases manifests diffidence as to whether Edison was, or was, not the inventor of the light bulb. In 1875, Henry Woodward and Matthew
Evans patented a light bulb, the rights for which were purchased by Edison. In 1878, Joseph Wilson Swan invented a light bulb whose lifetime was about 13.5 hours. Edison’s bulbs in 1880, derived using a filament derived from bamboo, lasted 1200 hours.
The issues in the 1895 case are not unrelated to those in LizardTech v. Earth Resource Mapping, 433 F.3d 1373; 2006 U.S. App. LEXIS 137; 77 U.S.P.Q.2D 1391 (CAFC 2006) and are not
unrelated to issues in the current discussion of alterations in the practice of continuing applications.
[Endnote 13, which appears here in the text, states: 71 Fed. Reg. 48 (Jan. 3, 2006). Abuses of applicants while awaiting developments in similar or parallel technology caused by amending the pending application to cover developments. If the
amendments are covered by the disclosure, this practice is allowed. PIN/NIP, 304 F.3d 1235.]
STEM CELLS
The situation faced by the courts in the 1880’s, in trying to figure out who made the step-out invention with the light bulb, will soon be faced by the courts of the 21st century, in trying to figure out who has made the step-out invention in embryonic stem cells. Although there are presently numerous patent applications on somatic cell nuclear transfer [SCNT] in various phases of generating embryonic stem cells, there are presently questions of scope of invention and of enablement, just as there were in the 19th century. Although many people are now claiming
large, with perhaps limited enablement and written description, the ultimate winner will be the person, who both identifies the insight to make the entire system happen and obtains patent
protection thereon.
UPDATE TO “YOU ONLY LOOK TWICE”
In the November 2005 issue of Intellectual Property Today, I presented some data on continuing applications for FY 2004 from the PTO, and noted the USPTO is evaluating the possibility
of limiting continuations, which crystallized in the Federal Register in January 2006. Two readers from Chicago, Kevin Noonan and Paul Reinfelds, sent along data for FY 2005, and noted, with the small number of “second” continuing applications, that the PTO proposal limiting continuing applications, even if effected, would not likely solve the problem faced by the PTO.
[Endnote 18 stated of the data for FY 2005: There were 63,000 continuing applications, which included 44,500 cons/cips and 18,500 divisionals. Of these, 11,800 were second, or subsequent, applications. Separately, there were 52,000 RCEs, of which 10,000 were second, or subsequent. Thus, 21,800 applications of
384,228, were second or subsequent, which is 5.7%. As for FY2004, RCEs were the single most abundant “continuing” form, 52,000 of 384,228 [13.5%]. All “continuing” forms combined
constituted 115,000 of 384,228 [30%]. The contents of Endnote 18 were cited in comments made to the USPTO about proposed rulemaking in the area of continuing applications:
www.uspto.gov/web/offices/pac/dapp/opla/comments/fpp_continuation/ebert.pdf.
The comments referred to my April 2006 article in Intellectual Property Today, which unknown to me at the time of the comments, was not actually published by Intellectual Property Today. These comments to the USPTO objected to the proposed limitations on second, and subsequent, continuing applications on the basis that, even if implemented, the proposed limitations would NOT resolve the application backlog problem AND separately would adversely impact many reasonable uses of continuing application practice.]
Of Carhart’s book, “Lost Triumph,” the publisher is Putnam, not Putman. Two other reviewers have discussed the novelty of the book, even though the theory about J.E.B. Stuart’s possible
role had been published years before Carhart’s book.
[After March 2006, the Supreme Court decided the case eBay v. MercExchange. Therein, the Supreme Court made clear that entities such as universities and individual inventors, who don't make product, could satisfy the four-factor test and obtain permanent injunctions to bar infringement of their patents.]
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