The World Stem Cell Summit is the flagship international event uniting the stem cell community by bringing together scientists, patients, advocates, business people, investors, educators, ethicists, policy makers, government representatives, and others to network and learn from each other.
In 2010, the Summit will attract more than 1,200 attendees from 30 nations, 60 exhibitors and more than 200 endorsing organizations and media partners from around the world.
Marriot Renaissance Center
Detroit, Michigan USA
www.worldstemcellsummit.com
Poster abstract submission deadlines July 30th 2010.
The 2010 World Stem Cell Summit is the largest and most comprehensive multi-track stem cell conference, featuring more than 150 international speakers and 50 hours of in-depth science, business and society presentations. No other stem cell conference offers the breadth of content and global perspective. The agenda works to unite, educate, and harmonize the global stem cell community.
This year’s diverse three-day program will include an array of opportunities to engage and educate attendees. Highlights include morning keynotes and plenary discussions, round table lunch conversations with experts, concurrent science, industry and society tracks, as well as intimate focus sessions designed to meet the needs of all World Stem Cell Summit attendees.
Stem Cells For Osteoarthritis: I Look Ten Years Younger Since my Facelift… But my Knees Still Feel Their Age… What Can I Do?
One of the first articles to mention stem cell therapy for osteoarthritis was an article published in the December 2003 article Arthritis and Rheumatism (Murphy JM, et al. Arthritis Rheum. 2003; 48: 3464-3474.)
The research team took two groups of goats and created osteoarthritis in their knees by removing the medial meniscus and cutting out the anterior cruciate ligament. After six weeks, one group of goats received an injection of sodium hyaluronan (a lubricant commonly used to treat symptomatic osteoarthritis of the knee) while the other group received a single dose of 10 million stem cells, originally extracted from the goats’ bone marrow, and then suspended in sodium hyaluronan before injection into the knee.
In the knees which had been treated by stem cell injections, researchers observed a regeneration of joint tissue and a decrease in cartilage degeneration.
The authors commented on their findings… “there may be a therapeutic benefit associated with local delivery of stem cells following traumatic injury to the knee. The longer term effect of this may be a reduction or delay in the progression to osteoarthritis.”
The authors concluded that “this is a scaffold-free method for cell delivery and is therefore unencumbered by the complexities associated with placement of a solid cell construct.” This latter statement is important because so many techniques to date have involved the complicated use of different scaffolds (frameworks) to hold stem cells in place.
Stem cells are progenitor cells- the cells that all others are derived from. They have three interesting characteristics that make them prime candidates for tissue regenerative techniques. They are capable of dividing and renewing their numbers for an unusually long period of time; they are undifferentiated, meaning they have not yet committed to being a “heart” cell or a “lung” cell; and they can become any type of specialized cell. Another term to refer to this property is that stem cells are “pluripotential.”
While most research and ethical concerns have been centered on the use of embryonic stem cells, adult stem cells are more accessible with no ethical “baggage.” The cells that were used in the above study were adult stem cells obtained from the bone marrow.
At the Arthritis and Osteoporosis Center of Maryland, research efforts have been aimed at using adult stem cells obtained from the bone marrow to treat osteoarthritis of the knee or hip. Stem cells are obtained from the iliac crest of the patient’s hip and then concentrated using a special technique. The area of interest- usually the medial compartment of the knee is then prepared with a special instrument under ultrasound guidance. This technique ensures that local inflammation is created at the site of needed repair. This is a critical component of the procedure since the exact location of pathology will determine where the stem cells will be placed.
Along with stem cells, platelet rich plasma, also obtained from the patients is infused. The platelet rich plasma attaches to tyrosine kinase receptors on the cell surface of the stem cells and triggers gene expression within the nucleus of the stem cell. This “turns on” the stem cell to divide and differentiate into cartilage.
The entire procedure is done using local anesthetic with ultrasound guidance.
According to Dr. Nathan Wei, “Preliminary results are very promising. Longer term data is required and we are specifically addressing not only patient function but also measurements of cartilage thickness.” He adds, “the best approach as far as framework preparation for the stem cells and ensuring an adequate number of stem cells are of key importance. If you don’t have enough viable stem cells, the procedure won’t be effective. Also, the stem cells need to be primed properly… and have a scaffold (framework) to attach to. “
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DrPeterDana asked:
Antiaging treatment with PRP Stemcell. Dr. Peter Dana in Marbella and Calpe-Costa Blanca. www.DrDana.de
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Check out these stem cell transplantation images:
Organica
Image by thomtrance
A Number
Image by TEDxNJLibraries
One-stop Shop
Image by jurvetson
Stem cell science
Re: Aug. 31 letters by Pat Knepley, “Tilting the debate,” and James Willis, “Wrong on the facts”: The highly emotional responses to Bonnie Erbe’s “Stem-cell ruling the height of cruelty” ignore some important information on the topic and thus give a distorted presentation of the subject. This calls for clarification.
Read more on Ventura County Star
Justice Department Appeals Stem Cell Research Ruling
Issue could mobilize conservative voters in midterm elections.
Read more on US News & World Report
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Some cool stem cell line images:
Stephen Minger
Image by dumplife (Mihai Romanciuc)
Stephen Minger
Image by dumplife (Mihai Romanciuc)
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Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. T
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